Asian Journal of Research in Chemistry

N. Srinath ¹, Y. Rajendra Prasad ², K. Mukkanti ³, N. K. Agarwal ²

Affiliations
1 Department of Pharmacy, Acharya Nagarjuna University, Guntur - 521250, IN
2 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530003, IN
3 Centre for Pharmaceutical Sciences, J N T University, Hyderabad – 500085, IN

Abstract

A variety of 2-amino-4-(3'-methyl-4'-hydroxyphenyl)-6-(substituted) pyrimidines were synthesized by reacting various chalcones with guanidine hydrochloride. The required chalcones were prepared by condensation of 3'-methyl-4'- hydroxyacetophenone with various substituted aromatic / heteroaromatic aldehydes in the presence of alkali. All these compounds were characterized by IR, ¹H NMR and Elemental analysis. The newly synthesized compounds were evaluated for their antimicrobial activity and some of them have shown significant activity when compared with the standard.

Keywords

Pyrimidines, Synthesis, Antimicrobial Activity.

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M. Srinivas ¹, Y. Rajendra Prasad ¹, S. Chandrashekaran ²

Affiliations
1 Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, IN
2 Enzene Biosciences Pvt. Ltd., Bangalore, IN

Abstract

An improved method for the synthesis of bicyclic pyrrolidines utilizing microwave-assisted synthesis is described. The synthesis involves microwave irradiation of an amine, aldehyde and maleimide in one pot fashion to give the desired product. The synthesized compounds were evaluated for their antibacterial activity against ciprofloxacin.

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